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Jelcic, I

For instance, exercise could foster a pro-inflammatory milieu (if directly or through sympathetic overload), in which GPCR dysfunction may be increased, which in turn may aggravate endothelial dysfunction (or vice versa)

Some high quality research has shown that MZRW improves symptoms in older adults with chronic constipation (22)

A number of explanations have been proposed to explain this
