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For chemotherapy side effects, a review of potential side effects and reassessment and making improvements after each cycle should be the goal

Sustained drug treatments suppress tumor angiogenic activity, leading to tumor-associated hypoxia, which promotes the selection of resistant cell clones adapted to oxygen and nutrient deprivation, thereby limiting drug efficacy [48]

32 TapiaL.Gonzalez-AgueroM.CisternasM

Linearity, concentration range, limit of detection (LOD), limit of quantification (LOQ), recovery and extraction efficiency and selectivity of the method were assessed
