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Adjunct drugs such as catechol-O-methyltransferase (COMT) and monoamine oxidase-B (MAO-B) inhibitors lack specificity to the central nervous system (CNS), have poor BBB permeability, and result in systemic side effects 15,16

In preclinical IBD models using nanoparticle delivery, KPV reduces inflammation, normalizes epithelial barrier markers, and lowers cytokine load

Thiol-specific peroxidase detoxifies peroxides, including sulphur, and radicals, assisting cells in defending against oxidative stress

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