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doi: 10.2337/db17-0413 11 Hanaire-BroutinHSallerin-CauteBPoncetMFTauberMBastideRChaleJJet al

The resulting damage intensifies cellular dysfunction and suppresses mitochondrial respiration, thereby aggravating the bioenergetic failure that underlies severe sepsis (Vctor et al., 2009

Enhancement of Endogenous Antioxidant Defense Network Considering the clearance rate of ROS by endogenous antioxidant defense network is often much higher than that of exogenous antioxidants, increasing endogenous antioxidant levels is a promising antioxidant therapy [167]

They include the catalytic (GCLC) [28] and modulatory (GCLM) [29] subunits of glutamate-cysteine ligase (rate-limiting synthesizing enzyme of GSH), glutathione-S-transferase [30, 31], superoxide dismutase-1 [32], nitric oxide synthase [33, 34]