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doi: 10.1371/journal.pbio.3000604 135 ZhangTTangYYangXWangXDingSHuangKet al

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While the pro-inflammatory effect of microcrystalline UA is well-established 3,20 , there are several indications that soluble UA free of UA crystals has protective effects against inflammatory mechanisms and toxicity 50 with effects on macrophage polarisation towards the anti-inflammatory M2 phenotype 51

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Astragaloside IV (AS-IV, C41H68O14), a significant component found in the aqueous extract of Astragalus membranaceus, is a cycloartane-type triterpene glycoside with proven biological properties (Zhang J

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First-line FDA-approved treatment relies on a multimodal approach of surgery, radiation, temozolomide (TMZ) chemotherapy, and tumor-treating fields

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