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NICE recommends more frequent injections (alternate days until no further improvement) for patients with neurological involvement

It makes it appropriate for a different use case: the person who already controls their diet, exercises consistently, and wants a modest additional push in fat mobilization without the gastrointestinal side effects, nausea, or hormonal disruption that come with GLP-1 agonists

If someone has a less efficient MTHFR variant, there would be less methylfolate, and therefore less methylcobalamin for converting homocysteine

AOD9604 was originally developed as an anti-obesity drug due to its lipolytic (fat burning) properties