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(data represented as meanS.D.).

In the endogenous apoptotic pathway, various cellular stress, such as nuclear DNA damage, cytokine deprivation, endoplasmic reticulum stress (ERs), lysosomal permeabilization, and oxidative stress generate intracellular death signals to promote mitochondrial dysfunction and subsequently mitochondrial outer membrane pore formation (MOMP)

AD is characterized by neuron degeneration in various cortical regions, leading to progressive memory loss and dementia

Seyler RW, Jr., Olson JW, Maier RJ
