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Nat Biotechnol (2012) 30(4):2956
For irritability, guanfacine IR tablets can be started at a daily dose of 1 mg, given as 0.5 mg (half of a 1 mg tablet) twice daily, and increased up to a maximum daily dose of 4 mg across two or more administrations
Recently published in vitro evidence suggests that cholinergic transmission is critical in suppressing glial proinflammatory cytokine production and enhancing intracellular A 142 clearance, synaptic plasticity and memory (Cantone et al., 2024
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