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As a result, altered intracellular glutathione homeostasis has been widely used as an indicator of oxidative stress

doi: 10.1002/dta.1941

Taken together, these shuttle mechanisms enable cells to maintain redox and energy homeostasis under a wide range of physiopathological conditions

Since cyst(e)inase treatment can induce intracellular cystine degradation consequent promotion of cancer cell ferroptosis [88], the combined cyst(e)inase with PD-L1 antibody effectively enhances tumor immunotherapy [86], suggesting that combined ferroptosis inducers with immune checkpoint inhibitors could effectively enhance cancer immunotherapy