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showed that ferroptosis inhibition improves depressive behavior in a chronic unpredictable mild stress mouse model [95, 96] Stress induced anxiety after 14 day chronic restrain stress showed ferroptosis, with higher oxidative stress and lipid peroxidation markers [97]

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Accordingly, our dosing is lower than that in prior studies in mice, which used 2501,000 mg/kg/day to model therapeutic effects against oxidative stress, teratogenicity, and neurobehavioral deficits (Parnell et al., 2010

10.1615/CritRevEukaryotGeneExpr.2024054463 [DOI] [PubMed] [Google Scholar] Limberger T., Schlederer M., Trachtov K., Garces de los Fayos Alonso I., Yang J., Hgler S., et al