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doi: 10.3389/fimmu.2026.1735598 Received 30 October 2025 Revised 03 February 2026 Accepted 04 February 2026 Published 18 February 2026 Volume 17 - 2026 Edited by Diego Kauffmann-Guerrero, LMU Munich University Hospital, Germany Reviewed by Anthony De Soyza, Newcastle University, United Kingdom Susanne Nhrig, LMU Munich University Hospital, Germany Updates Copyright 2026 Yu, Zhu, Jin, Ding and Jin

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In this regard, the implementation of in vivo animal studies and clinical trials to evaluate the suicidal death of erythrocytes in tissue and organ contexts represents a key objective to be pursued

Among these, a ChaC domain-containing effector, called RipAY, was identified [145]