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Topiramate can induce AACG within the rst 2 weeks after initiation, and in almost all cases present in both eyes [8] Ecstasy, a synthetic amphetamine derivate, and marijuana have both been reported to induce recurrent bilateral AACG [9]

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Deficiency of 5-methyladenosine phosphorylase (MTAP), a key enzyme in polyamine metabolism in tumors, can accelerate the accumulation of 5-deoxy-5methylthioadenosine (MTA) in the TME, ultimately reducing the maturation of dendritic cells and the activation of T cells