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Description
L-asparaginase anti-tumor activity in pancreatic cancer is dependent on its glutaminase activity and resistance is mediated by glutamine synthetase

Apoptosis signal-regulating kinase 1 (ASK1) is a serine/threonine protein kinase and activates JNK and p38 pathways

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The balance between activation and detoxification by xenobiotic-metabolizing enzymes is often a key determinant of chemical toxicity, and often the basis for organ or species differences in toxicity