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Description
Factors affecting drug bioavailability in space
Impaired acidification, fusion defects and reduced endosomeautophagosomelysosome pathway flux compromise the clearance of pathogenic aggregates, and raising cellular cAMP or free zinc has been proposed as a strategy to restore lysosomal pH and proteolytic capacity in affected neurons 166
Sawaki et al., 2009) suggesting that Al post-transcriptionally modulates AtSTOP1
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