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The ROS generation ability of the membrane was reduced by 40% after gliotoxin treatment [29,59,60], and the in vitro addition of gliotoxin to flavocytochrome b558 and cytosolic components also exhibited an inhibition rate of 50% with the concentration of 3.3 M [60], suggesting that flavocytochrome b558 is the target of gliotoxin

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Many receptors only fold correctly, or only present the binding surface a drug needs to hit, when they are sitting in a cell membrane with their full transmembrane and cytoplasmic regions attached and the right lipid environment around them