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Along the aging, circadian rhythm is progressively perturbed and circulating IGF-1 level is reduced, resulting in defects in multiple systematic physiological functions (Tevy et al., 2013)

PubMed Central , World Journal of Gastroenterology : WJG , vol

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395 Similarly, lncRNAs can act as competing endogenous RNAs (ceRNAs), sequestering miRNAs and affecting their regulatory functions
