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Research has revealed, new MS susceptibility forms linked to immune function, alongside the human leukocyte antigen (HLA) complex (Korn 2008)

The oxidative stress markers, GSH and MDA did not show significant differences across study groups or consistent correlations with vanin-1 or PA

& Greenwood, J

We hypothesize that (i) the slow inhibition observed in the biochemical assay with the recombinant protein with some of the compounds is due to their preferential binding to a slowly populated conformer of the NADP + -TGR(H) complex and (ii) this conformer is already populated in the worm cell interior accounting for the more rapid inhibition of TGR observed in ex vivo worms with the slow inhibitors