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Further, several molecules, including tumor necrosis factor alpha (TNF), leptin, -amyloid, delta-sleep inducing peptide (DSIP), and prostaglandin D2 (PGD2) display changes of rhythmic entry into murine CNS ( Bmal1 deficient mice display hyperpermeability and downregulation of platelet-derived growth factor receptor (PDGFR), suggesting a significant role for Bmal1 in pericyte regulation for blood-brain barrier maintenance (Nakazato et al., 2017)

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The increase of free iron leads to Fenton reaction (Fe 2+ + H 2 O 2 Fe 3+ + OH + OH ), resulting in ROS accumulation and non-enzymatic lipid peroxidation, which leads to the imbalance of antioxidant system and membrane integrity defect, and finally leads to ferroptosis (Forcina and Dixon 2019) (Fig

doi: 10.1016/j.expneurol.2006.07.022
