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Studies on human did not show toxic effects, and curcumin was safe at the dose of 6 g/day orally for 47 weeks

11 Furthermore, hyperglycemia itself, resulting from insulin resistance, induces a pro-inflammatory environment through its effect on immune cells

doi: 10.1038/s41576-018-0018-x 121 ToupsK.HathawayA.GordonD.ChungH.RajiC.BoydA.et al

Figure 4 The NLRP3 inflammasome is one of the most studied and well-understood multiprotein complexes and has been linked to ferroptosis
