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Taking these drawbacks into consideration, the prodrugs of EGCG analogs were synthesized with the compounds identified as 2a and 4a having lower susceptibility to be metabolized or inhibited by COMT and having an amplified antiproliferative, antiangiogenic, and antifibrotic effect in HuLM ( Scutellaria barbata D
675,676,677,678,679,680,681 These studies have implicated that GITR agonists alone could not reactivate the cytolytic function of T cells in tumor environment, and combinatorial approaches of GITR agonism and other immunomodulatory therapies are of great interest

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