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Thus increased stretch and its subsequent stimulation of vascular oxidant stress may contribute to the cellular dysfunction encountered in the wall of varicose veins (Figure 3) [62]

10.3389/fcell.2020.00055 [DOI] [PMC free article] [PubMed] [Google Scholar] Watanabe H., Saito H., Rychahou P

12 Furthermore, minerals and trace elements have essential roles, such as hormone regulation during the menstrual cycle, ensuring proper ovarian function and ovulation, maintaining endometrium health and receptivity for implantation, and regulating oxidative stress via antioxidant processes to prevent damage to cellular structures

PMID 19524038