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Increased levels of miR-144 have been found in a subset of HbSS patients with typical severe anemia and reduced NRF2 protein levels, causing a reduction of GSH regeneration and impairing cell response to OS, thereby providing a possible mechanism for the increased anemia severity seen in these patients [221]

However, the molecular mechanisms of nutritionally mediated oxidative stress are complex and poorly understood

Due to the unique nature of the lung interfacing directly with the environment, maintenance processes are believed to be ongoing, but in the setting of a stress such as cigarette smoke, critical alveolar maintenance programs are disrupted

Surprisingly, Gclc KO mice showed no signs of liver damage, both by histology and serum biochemistry markers (Fig