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Data compiled by SHOOK Research LLC based on the time period from 3/31/21 - 3/31/22

Roxadustat impairs the neuronal redox balance through a PFKFB3-dependent reduction of NADPH production in the pentose phosphate pathway Cumulative evidence indicates that neurons have a lower glycolytic rate than astrocytes, and a significant proportion of glucose-6-phosphate (G6P) is directed towards the pentose-phosphate pathway (PPP) 41 , 42

Bystander killing effect of DS 8201a, a novel antihuman epidermal growth factor receptor 2 antibodydrug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity