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Under normal conditions, Fe 2+ is largely imported by membrane iron transport protein (FPN) on the basolateral membrane of the duodenum, where it is oxidized to Fe 3+ and then collected by transferrin (Tf) in plasma (70)

The -glucans found in mushrooms like Ab have a -(13) structure associated with -(16), which is able to stimulate cellular and humoral immune response, increase NO production, phagocytosis and lymphocyte proliferation (1315)

Histamine challenge/provocation test has also been proposed by some authors as a diagnostic tool for intolerance, which would, at the same time, establish the individual tolerance threshold

doi: 10.1016/j.ccell.2022.02.003 55 BrownCWAmanteJJGoelHLMercurioAM