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In SV40-MES 13 cells, HMGB1 (high-mobility group box-1) has been recognized as a valuable factor of ferroptosis based on the Nrf2/HO-1 signaling pathway, proposing that HMGB1 is a new target for the treatment of DN [157]
[Google Scholar] Islam M.M., Wallin R., Wynn R.M., Conway M., Fujii H., Mobley J.A., Chuang D.T., Hutson S.M
[44] reported that SOCS1 and SOCS3 inhibited the signaling of insulin receptor by inducing a ubiquitin-mediated degradation of IRS1 and IRS2 proteins (Fig
