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Mice lacking the clock activator Bmal1 in adipocytes ( Bmal1 knockout (KO)) displayed reduced mitochondrial OCR in response to pyruvate during the dark period (ZT14) compared with mice with an intact clock

In the initial stages of obesity, the uptake of fatty acids and glucose by adipocytes leads to the activation of NOX4, the major isoform of NADPH oxidase found in adipocytes, resulting in the increased production of ROS [57,58,59]

Controlled endocrine investigations demonstrate stable cortisol or corticosterone concentrations despite measurable growth hormone pulses, supporting limited hypothalamic-pituitary-adrenal axis engagement in experimental models

doi:10.1016/j.jaci.2013.07.046 Tigner, Alyssa, et al