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DSIP readily crosses the blood-brain barrier to exert central effects and may enhance inhibitory neuronal activity or modulate sleep-regulating brain regions
216 - 224 Journal articles | 2009 Eggers PK
Studies suggest that a significant proportion of long-term metformin users may develop biochemical B12 deficiency, though estimates vary widely depending on the population studied, the duration of use, and the B12 threshold applied
