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Repeated injections of DSIP in a 35-year-old male narcoleptic investigated the effects of the neuropeptide on these very symptoms and concluded that DSIP reduced the frequency of daytime sleep attacks and increased the individual's daytime performance in terms of overall alertness and activity

The temporal association of intestinal dysbiosis, subclinical gut inflammation, and leaky gut with the onset of arthritis in animal models may suggest a mechanistic link between increased intestinal permeability and RA pathogenesis in accordance with the mucosal hypothesis

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