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They have not been reviewed, evaluated, or approved by the U.S

Vitamin C and antibiotics: Taking vitamin C in conjunction with certain antibiotics, including tetracycline, minocycline, or doxycycline, can increase blood levels of the antibiotic and decrease the effectiveness of vitamin C

I'll occasionally take it every once in a while, but in general, I just stopped taking it because whatever the positive effects might've been, if I had taken it more consistently, the effects in depleting rapid eye movement sleep were just something I didn't want and don't want