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The excretion of calcium by the body is not increased following intravenous administration of edetate calcium disodium, but the excretion of zinc is considerably increased

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J Am Acad Dermatol 76(1):2228
ROS are generated within the inner mitochondrial membrane as byproducts of oxidative phosphorylation (OXPHOS), making mitochondria a major source of intracellular ROS [37, 38]
