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Description
further modified the anterior model by intradiscal injection of saline into rat lumbar IVDs, which resulted in increased pain, as evaluated by increased grooming duration, decreased mechanical withdrawal thresholds, and decreased thermal withdrawal latency

This results in inflammation of both tissue and joints

It upregulates p63 and integrins in epidermal stem cells, increases collagen, glycosaminoglycans, and decorin expression

doi: 10.1111/bph.14617