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While IGF-1 LR3 was engineered for extended half-life and systemic activity, IGF-1 DES follows the opposite strategy: very short half-life (20-30 minutes) but extreme potency at the site of injection

Nat Genet 37(4):391400 Benard A, Goossens-Beumer IJ, van Hoesel AQ, Horati H, de Graaf W, Putter H, Zeestraten ECM, Liefers G, van de Velde CJH, Kuppen PJK (2015) Nuclear expression of histone deacetylases and their histone modifications predicts clinical outcome in colorectal cancer

Polysaccharides from Cibotium barometz improved mitochondrial gene expression and muscular integrity, while pomegranate-derived complexes produced a twofold increase in antioxidant indices [72,122]

doi: 10.1136/bmjopen-2013-004587 195 OpherkCTroncheFKellendonkCKohlmllerDSchulzeASchmidWet al
