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This reflects a key implication in malignancies, whose intrinsic environment is highly dependent on glycolysis, as characterized by the Warburg effect

This would mean that each SC sequesters its own subpopulation of the mobile electron carriers (CoQ and/or cytochrome c ) and electron transfer between two sequential enzymes (CI-CIII and CIII-CIV) occurs by successive reduction and reoxidation of the mobile intermediates that are enclosed in internal channels connecting one enzyme active site to another (50, 61)

It appears that old age per se is not a risk factor for APAP toxicity, however, co-morbidities with impaired liver function, low body weight, polypharmacy, etc

Arneth B., Tumor Microenvironment, MedicinaLithuania 56, no