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The answer lies in a concept called bioavailability

The defensive effect of benfotiamine in sodium arsenite-induced experimental vascular endothelial dysfunction

Clarified supernatant was kept after spinning at 13.2 rpm for 15 min, and a total of 40 l was taken to determine the expression of endogenous protein

[7] Published Rodent Toxicology Observations Published rodent studies employing BPC-157 across a range of experimental protocols including gastrointestinal cytoprotection studies, tendon and ligament repair models, dermal wound healing studies, vascular injury models, and central nervous system research have generated safety-relevant data that, while often collected alongside efficacy endpoints, provides the most comprehensive picture currently available of BPC-157s preclinical toxicology profile