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Up-regulation of mitochondrial antioxidant capacity, either by direct infusion of ROS scavengers [16] or increased protein expression [17, 18] results in cardioprotection

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Further investigation into the testicular microenvironment using a co-culture system of senescent TM3 Leydig cells and GC-1 spg spermatogonia revealed that H2O2-induced senescent TM3 cells secreted increased levels of SASP factors, particularly IL-6 and TGF-