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When CD47 binds to SIRP on dendritic cells and macrophages, it activates an immunoreceptor tyrosine-based inhibitory motif that suppresses phagocytosis (61)

Limiting time in aqueous solution reduces all degradation pathways, including any unexpected interactions

This article walks through what the before and after timeline actually looks like at 3, 6, and 12 months based on clinical observations from our patient population, what affects the magnitude of results, and who is the right candidate for this protocol

Storage: Store at room temperature until reconstituted- following reconstitution, solution is stable when refrigerated for 60 days