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The in vivo inhibition of IP6K decreased plasma phosphate levels without inhibiting gut intake or kidney reuptake of phosphate, demonstrating a pivotal role of IP6K-regulated cellular phosphate export on circulating phosphate levels

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Intracellular copper could stabilize the HIF1A (hypoxia inducible factor 1 subunit alpha) protein via inhibiting PHD (prolyl-4-hydroxylase domain) enzymes in liver cancer cells [154]