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however, if the patients were HBeAg-negative or previously had received treatment with nucleos(t)ide viral replication inhibitors (NUCs), the therapeutic effect was significantly reduced

That is a significant reduction

[DOI] [PMC free article] [PubMed] [Google Scholar] 93.Basit F, van Oppen LM, Schckel L, Bossenbroek HM, van Emst-de Vries SE, Hermeling JC, et al

According to recent research, KD and the induced BHB delay DKD progression by improving the metabolism of glucose and lipids, regulating autophagy, as well as alleviating inflammation, oxidative stress and fibrosis