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The sample was vigorously shaken on an MX-F vortex mixer (Dragon Laboratory Instruments Ltd., Beijing, China) for 1 min before dissolution by an ultrasonicate (Kunshan Ultrasonic Instruments Co., Ltd., Kunshan, China) for 20 min

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Traditionally, caffeine has been described as a potential drug of abuse, and it is widely stated that consuming too many caffeinated drinks is unhealthy ( The chemical structure of caffeine contains a purine ring, which chemically resembles adenosine and is a natural non-selective receptor antagonist of adenosine (Figure 1) (Wang et al., 2015

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