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2021;19 doi: 10.3390/md19040201

In hereditary or acquired metabolic defects, an initial intravenous bolus of 50 mg/kg may be administered over two to three minutes, followed by maintenance doses of 50 mg/kg every six hours or continuous infusion to achieve a total daily exposure of up to 300 mg/kg in critical illness

This review has systematically explored the role of dietary polyphenolsparticularly curcumin, quercetin, baicalein, luteolin, and resveratroland their interaction with hepatic transcriptional regulators, including SREBP-1c, PPAR, PPAR, LXR, FXR, RXR, and RAR
