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Description
(DHFR = dihydrofolate reductase
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Cell cycle arrest: Metformin is also able to block glioma cells in specific cell cycle phases, such as G0/G1 or G2/M, by affecting the expression of cell cycle regulatory proteins
Notably, LPC (16:0), a lipid oxidation product, is elevated in FM and directly activates acid-sensing ion channel 3 (ASIC3) on nociceptors, leading to hyperalgesia in animal models (13)
