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Validation of these observations has been done experimentally by quantitation of 8-Oxo-2-deoxyguanosine (8-OHdG), a known marker of oxidative stress-mediated damage to DNA 30 in DNA digests from tumor tissues and blood lymphocytes

Acknowledgments This work is part of the collaboration between the Department of Radiobiology and Molecular Genetics, VINA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia, Clinic for Internal Medicine, Department of Endocrinology and Diabetes, Zemun Clinical Hospital, School of Medicine, University of Belgrade, Belgrade, Serbia, and KAUST

10.1186/s12913-016-1423-5 Adv Integr Med

defined primary cerebral folate deficiency as a neurological syndrome associated with normal levels of extraneurological folate but reduced levels of 5-methyltetrahydrofolate (5MTHF), a folate metabolite in cerebrospinal fluid [101]