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Moreover, high levels of certain metals, like Fe, Ni, and Cu, can initiate oxidative stress by reacting with naturally occurring hydrogen peroxide to produce hydroxyl radicals [82]

Furthermore, if the current rate of increase in prevalence continues, costs could reach nearly $15 trillion of lifelong costs by 2029 [171]

In animal research, significant reductions in body weight gain were observed over treatment periods of 14-19 days, with sustained effects during chronic administration

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