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Postmortem studies (Nelson and Xu, 2023) reveal elevated OS and p53 phosphorylation in AD brains, suppressing DNA damage response (DDR) and double-strand break (DSB) repairpotentially contributing to neuronal loss and offering new therapeutic targets

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fmr1 mutant PyrN at middle exhibited a moderate reduction in dendrite arbor size, whereas fmr1 mutant PyrN at right exhibited severely impaired dendrite growth
