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J., Tao Y., et al., Arctigenin Disrupts NLRP3 Inflammasome Assembly in Colonic Macrophages via Downregulating Fatty Acid Oxidation to Prevent Colitisassociated Cancer, Cancer Letters 491 (2020): 162179

The glutamine metabolism-related proteins, such as GLS-1, glutamate dehydrogenase (GDH), and ASCT2 were found to be highly expressed in HER2-positive breast cancer than other subtypes, which indicated that HER2-positive breast cancer had the highest glutamine metabolism activity ( One-carbon metabolism, also known as network of folate utilization reactions, participates in multiple metabolic pathways such as amino acid biosynthesis and degradation, de novo nucleotide biosynthesis, and methylation and reductive metabolism (49)

Beyin fonksiyonlar asndan glutatyon, nrotransmitterlerin metabolizmasna katlr, kan-beyin bariyerinin btnln korur ve nroinflamasyonu azaltr

SAM acts as a key methyl donor for most methylation modifications, including the methylation of DNA, RNA, lipids and histones, and also participates in polyamine biosynthesis, which has a function in multiple cellular processes including regulation of chromatin structure, transcription and translation, DNA stabilization, cell growth and proliferation [50]