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B12 is water-soluble, so any excess is naturally eliminated through urine

For a 70 kg individual, this translates to approximately 1.75-28 mg per dose, though standard therapeutic protocols use significantly lower daily doses

In addition, cationic nanoparticles (CNP-siCCR2) encapsulated with siCCR2 can effectively inhibit the expression of CCR2 in monocytes and blocking the recruitment of monocytes to tumor tissues thereby changing the tumor immune microenvironment, inhibiting primary tumor growth and reducing tumor metastasis, and improving the anti-tumor effect of chemotherapy drugs (29)

Jia Z, Song Z, Zhao Y, Wang X, Liu P