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Acknowledgements We are grateful for the financial support from the National Natural Science Foundation of China (32071342 and 32101065), the Science, Technology & Innovation Commission of Shenzhen Municipality (JCYJ20220818102810023), and the Singapore National Research Foundation under Its Competitive Research Program (NRF-CRP26-2021-0002)

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10.1016/j.cbi.2017.11.012 Chem

This sequence ensures peptides penetrate before heavier products create barrier while supporting ingredients enhance rather than interfere with dark circle improvement mechanisms
