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Acknowledgements The figures were created using images from the Icon Library on www.biorender.com

H 2 O 2 caused approximately over 37% of LDH leakage, while RGD-GHK and sOtx2-GHK attenuated H 2 O 2 -induced LDH release by 12% and 10%, respectively, as shown in Figure 4C

This detoxification of blood from the gut protects the rest of the body from excessive immune activation and influences the unique immunological environment within the liver

98 Consequently, minimizing the clearance rate of nanoparticles from the body and enhancing their selective accumulation in target areas are critical for the clinical application of nanotechnology