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Examine.com reports most benefits are from animal studies

Yes, combining B12 therapy with physical therapy and pain management can enhance treatment

Norris AW, Ode KL, Merjaneh L, Sanda S, Yi Y, Sun X, et al

Apart from the common characteristic of anemia (decrease in red blood cells), anemia due to B12 deficiency presents a process of macrocytosis (increase in the size of red blood cells or erythrocytes) that manifests itself in the abnormal growth of blood cells (the aforementioned megaloblasts), all of which is the result of a failure of their nucleus to mature and an increase in cytoplasmic mass and maturation