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Indeed, inactivating Keap1 has been shown to rescue a phenotype of diet-induced steatohepatitis reported in Adh5 / mice 47
This activity of IRE1 is independent of its role in regulating the UPR and is evolutionarily conserved
Our results revealed that MTX significantly induced the elevation of transaminases, alkaline phosphates (ALP), lactate dehydrogenase (LDH), and malonaldehyde (MDA) while depleting the levels of superoxide dismutase (SOD) and glutathione (GSH) when compared to the control group
doi: 10.3390/nu11092128
